The Weapon against Erectile Dysfunction: Cheap Tadalafil

Buy Cialis Online

Today, in the age of information technology, it is no longer surprising that you can order medicines by phone, on the website or in mobile applications of pharmacies, and they will be delivered to your home or to your local post office. However, even a couple of years ago, before the COVID-19 pandemic, this way of purchasing medicines was far from widely used. But troubles are the force that moves the progress forward, and today every fourth American makes orders in online pharmacies. This is absolutely easy and requires just several minutes of your time and basic browser search skills.

The process of making a purchase is similar to purchasing any product in an online store, so if you want to buy Cialis online, you should not be afraid that there will be any difficulties along the way. Besides the fact that you can save a lot of time, which can be spent on much more pleasant things than driving to the local pharmacies, you can also save money, because the prices of drugs for erectile dysfunction in online pharmacies are always lower than in conventional pharmacies.

Buy Cialis Online Safely

With online orders, if you do not follow certain precautions, there is a risk of getting a fake instead of a full-fledged medicine. So you can lose not only money, but also health. Some scammers create fake websites or try to sell underpriced medicines without a license or other necessary permissions. In order not to buy a fake and not pay money to scammers, you need to check the information about the pharmacy in advance.

Check if the name of the pharmacy or pharmacy chain is on the list of credible large online pharmacies on any site aggregating such information.

Read the information on the site. There must be placed the details of the seller as a legal entity, the conditions for distance selling, a copy of the license. These data must be present, regardless of the country in which the pharmacy is registered.

Check the contents of the order upon receipt. Open the box, make sure that the terms of delivery are met, inspect the packaging. Be sure to check the shelf life.

Cheap Generic Cialis

The original Cialis from Elli Lilly has been on the market since 2002. Since the patent protection for Cialis expired in November 2017, some generic drugs have been available on the market since then.

Getting generic Cialis, you can save a lot of money. Search for cheap generic Cialis in international and foreign national online drugstores, mainly in Indian ones. This country is well-known for its high quality and affordable medications.

Even when buying larger packs and higher dosages, you can usually stay in profit. If you are taking lower dosages, you can still purchase the maximum dosage pack. You can then use a pill splitter to divide the tablets into the correct dosage.

Cialis Generic Best Price

If you are looking for generic Cialis at best price possible, focus on search in Indian online pharmacies. Production and export of generics of a wide variety of medicines, including Cialis, is a key priority for the Indian pharmaceutical industry. You may not just look for the cheapest offer, but search for current discounts and promotions, which are often indicated on aggregator websites. Choosing between the dosages available (5, 10 and 20 mg), it is better to select 20 mg. This option is most popular as the cheapest of all available, since one pill can be divided into at least two doses. As a result, one dosage costs less.

When ordering Cialis generics, keep in mind that in large online pharmacies that are most trusted by customers, the cost of a pill is inversely proportional to the number of pills in the order. You can consider yourself a really lucky man if you find an offer with the price of around $1,2 for one 20 mg Tadalafil pill.

Basic Info

Erectile dysfunction is now a widespread disease affecting both older men and men of middle and even younger age. The medical community has long been concerned that male sexual diseases are getting younger. The issue of treating the symptoms of erectile dysfunction is now very relevant. In this regard, many methods have been developed for the treatment of this disease and a variety of pharmaceuticals, among which Cialis is recognized as one of the most effective ways to cure this disease.

Cialis is a tablet drug with the active ingredient Tadalafil, which is a powerful inhibitor of the PDE-5 enzyme with a high degree of selectivity. Tadalafil is developed to relax the smooth muscles in the vessels of the penis, mainly in the cavernous bodies. This effect is achieved because the drug, by blocking the production of the PDE-5 enzyme, dilates blood vessels and helps to increase blood flow in the penis, to increase the level of pressure in it. Thanks to this, a long-lasting strong erection is achieved.

Cialis has shown itself to be an effective and safe remedy for restoring not only erection, but also sexual life of a man in general. Its use is simple and does not involve any medical manipulations that can discourage a man’s partner from having sex with him, as is often the case when necessary to use treatments such as intracavernous injections. Moreover, by using the drug in question, due to its reliability and high efficiency, it is possible to completely eliminate erectile dysfunction without professional medical intervention, which, of course, can be considered as one of the main positive qualities of this drug. In addition, Cialis, due to the high selectivity of its active substance, is distinguished by the fact that it causes significantly fewer side effects than other drugs to increase potency, which belong to the category of PDE-5 inhibitors.

Another significant advantage in terms of the functioning of Cialis is that the effect of its action occurs only when sexual desire is manifested. It can be both “moral” in origin (when a man is in the mood for sex and emotionally aroused), or physical, when he experiences stimulation of the erogenous zones, mainly the genitals. This causes a nuance that it is desirable to take into account in the process of using Cialis: taking pills in a state of sexual arousal, that is, if there is a desire to have sexual intercourse, contributes to a more effective effect of the drug. Tadalafil has no effect in the treatment of erectile dysfunction in the absence of libido.

Cialis should be taken no more than once a day and at least 15 minutes before the intended proximity. The manufacturer considers such a frequency of taking his product to be quite sufficient for the full sexual functioning of the male body. The effect of the drug lasts 36 hours. This feature of Cialis allowed its manufacturer, the American pharmaceutical company Eli Lilly, to advertise it as a “weekend pill”. By taking one pill, a man can be sure that he will be ready for sexual exploits for at least a day and a half.

After the intake, Tadalafil is rapidly absorbed into the blood. The average maximum concentration of this substance in the blood plasma is reached approximately 2 hours after ingestion. It is at this time that the most vivid sexual activity is possible.

It is important that the rate and degree of absorption of Tadalafil do not depend on the time of the meal, so Cialis can be used regardless of the meal, while other PDE-5 inhibitors are more effective on an empty stomach. The time of administration (morning or evening) does not have a clinically significant effect on the rate and extent of absorption of the drug.

To date, in addition to the standard “on demand” use in the treatment of erectile dysfunction, for the treatment of benign prostatic hyperplasia (BPH), the FDA has approved the use of Cialis on a daily basis at a dosage of 5 mg (less often – 2.5 mg for patients with comorbidities which refer to the limitations for taking Tadalafil).

When taking the drug once a day, the equilibrium concentration in the blood plasma is reached within 5 days. It is after this period that the medicine really begins to act.

The pharmacokinetics of Tadalafil, determined by the population method in patients with erectile dysfunction, is similar to the pharmacokinetics of the drug in patients without erectile dysfunction.

It is of interest to ask why Tadalafil was approved as a treatment for BPH. In the smooth muscle of the prostate, bladder, and blood vessels that supply them, PDE-5 inhibition has the same effect on cGMP concentration as it does on the smooth muscle of the cavernous bodies of the penis. As a result, the smooth muscles of the prostate vessels relax, which leads to an increase in blood perfusion and, as a result, to a decrease in the severity of symptoms of BPH. Inhibition of afferent bladder nerve activity and relaxation of prostate and bladder smooth muscle may further enhance vascular effects.

Indications

The main indications for taking Cialis, on the basis of which doctors recommend a more or less long-term use of this medication, are as follows:

Of course, this list is not final, and each doctor considers it in the direction of narrowing or expanding in relation to a particular patient. In addition, Cialis can be used periodically on demand in cases where a man is uncertain that he will be able to make a full-fledged sexual contact due to his fatigue, anxiety or other factors that adversely affect potency (mainly psychological ones). If a man is not aroused by his partner, or his libido is lowered because of hormonal failure, taking certain medications, or for other reasons, there is no point in taking Cialis, since to ensure the effect of Tadalafil, a situation “I want, but cannot” is necessary, and not “I don’t want and I can’t”.

Contraindications

The basic contraindication to taking Cialis is hypersensitivity to Tadalafil or to any other substance that is part of the drug. In practice, this condition is extremely rare and is in the nature of a strong allergic reaction.

Cialis is contraindicated in the case of taking drugs containing any organic nitrates. Clinical studies have shown that Tadalafil enhances the hypotensive effect of nitrates, which can lead to a sharp decrease in pressure, loss of consciousness and even death. This is believed to be due to the combined effects of nitrates and tadalafil on the nitric oxide/cGMP metabolic pathway.

This medicine is not used in persons under 18 years of age.

The most important point regarding contraindications to taking Cialis is the presence of contraindications to sexual activity in patients with diseases of the cardiovascular system. By themselves, many diseases of the cardiovascular system are not factors for avoiding Tadalafil, but clinicians should consider the possible cardiac risk of sexual activity in patients with a history of cardiovascular disease. The following groups of patients with diseases of the cardiovascular system were not included in clinical studies, and therefore tadalafil is contraindicated for them: patients with myocardial infarction within the last 90 days, patients with unstable angina or an angina attack during intercourse, patients with chronic heart failure of class II and above according to the NYHA classification within the last 6 months, patients with uncontrolled arrhythmias, arterial hypotension (BP less than 90/50 mm Hg), uncontrolled arterial hypertension, patients with stroke within the last 6 months.

This medicine should not be taken by men with loss of vision in one eye due to non-arterial anterior ischemic optic neuropathy (regardless of the connection with the previous intake of PDE-5 inhibitors).

Simultaneous use of Cialis with doxazosin, with other PDE-5 inhibitors and other treatment options for erectile dysfunction is prohibited. Co-administration of Tadalafil with guanylate cyclase stimulants such as Riociguat is contraindicated as it may lead to symptomatic hypotension.

It is forbidden to use Cialis in patients with severe chronic renal failure, rare hereditary galactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome.
With caution, Cialis is prescribed to patients with severe liver failure, with a predisposition to priapism (with sickle cell anemia, multiple myeloma or leukemia) or in patients with anatomical deformity of the penis (angular curvature, cavernous fibrosis or Peyronie’s disease).

Interaction with other drugs

Restriction to taking Cialis is the simultaneous use with inhibitors of the CYP3A4 isoenzyme (ritonavir, saquinavir, ketoconazole, itraconazole, clarithromycin, erythromycin, grapefruit juice), antihypertensive drugs, 5-alpha reductase inhibitors.

Cialis is also not recommended for patients taking alpha-blockers, since simultaneous use in some cases can lead to symptomatic arterial hypotension.